A trial to test if the combination of encorafenib, binimetinib and cetuximab is safe and effective in participants with BRAFV600E-mutant metastatic colorectal cancer.

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Phase 2, open-label, single arm, multicenter study of Encorafenib, Binimetinib plus Cetuximab in subjects with previously untreated BRAFV600E -mutant metastatic colorectal cancer

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Status
Status :
Active not recruiting
Type of study
Phase II
Min. Age
18
Years old
Max. Age
-
Gender
All

Brief summary

The purpose of the trial is to find out whether combining three different medicines, encorafenib, binimetinib and cetuximab is safe and effective in people with metastatic colorectal cancer carrying a specific mutation in the BRAF gene (BRAFV600E) and who had not previously received any therapy for their disease.
Encorafenib, binimetinib and cetuximab may turn off the effect of this BRAF mutation, each acting in a different way.

Therapeutic area :
Oncology
Disease :
BRAFV600E - mutant metastatic colorectal cancer
Study medication :
Encorafenib (BRAFTOVI®) - Binimetinib (MEKTOVI®) - Cetuximab (ERBITUX®)
Phase : Phase II
Start Date :
14 January 2019
End Date / Planned study Completion Date :
March 2023
Study ID : W00090GE201
EudraCT/CTIS number : 2018-000271-32
CT.gov Number : NCT03693170
Countries :
Austria
Belgium
France
Germany
Italy
Japan
Netherlands
Spain
United Kingdom
United States

Find out where the clinical trial is / was conducted

1

Washington University

660 South Euclid Ave, CB8069
Saint louis, MO 63110
United States

2

Virginia Cancer Specialists

8503 Arlington Blvd. Ste. 400
Fairfax, VA 22031
United States

3

University of Colorado Cancer Center

1665 Aurora Court Anschutz Cancer Pavilion
Aurora, CO 80045
United States

4

University of Kansas Medical Center Research Institute, Inc.

2330 Shawnee Mission Parkway Suite 210 - Mailstop 5003
Westwood, KS 66205
United States

5

USC Norris Comprehensive Cancer Center

1441 Eastlake Avenue. Room 1335
Los angeles, CA 90033
United States

6

The West Clinic

West Cancer Center 7945 Wolf River Boulevard
Germantown tennessee, TN 38138
United States

7

Smilow Cancer Hospital at Yale New Haven

266 South Frontage Road Room 8-110
New haven, CT 06510
United States

8

Scott & White Memorial Hospital

2401 South 31st Street
Temple, TX 76508
United States

9

Memorial Sloan Kettering Cancer Center

1275 York Ave, Howard Bldg, Rm 1102
New york, NY 10065-6007
United States

10

City of Hope Cancer Center

1500 East Duarte Road Building 171, Room, 1072
Duarte, CA 91010
United States

11

Torbay Hospital

Lowes Bridge
Torquay devon
TQ2 7AA
United Kingdom

12

The Christie

Wilmslow Road
Manchester
M20 4BX
United Kingdom

13

Royal Marsden Hospital - Fulham

Fulham Road
London
SW3 6JJ
United Kingdom

14

St James's University Hospital

Level 4, Bexley Wing Beckett Street West Yorkshire
Leeds
LS9 7TF
United Kingdom

15

Guy's Hospital

15 St Thomas Street Ground Floor, Mary Sheridan House
London
SE1 9RT
United Kingdom

16

Queen's Hospital

Rom Valley Way Essex
Romford
RM7 0AG
United Kingdom

17

Beatson West of Scotland Cancer Centre

1053 Great Western Road Strathclyde
Glasgow
G120YN
United Kingdom

18

ICO l'Hospitalet - Hospital Duran i Reynals

Avinguda Gran Via de l'Hospitalet, 199-203
08908 Lhospitalet de llobregat
Spain

19

Hospital Universitario Puerta de Hierro Majadahonda

Manuel de Falla, 1 Oncologia - 2ª planta
28222 Majadahonda madrid
Spain

20

Hospital de la Santa Creu i Sant Pau

Sant Quintí Nº89
08041 Barcelona
Spain

21

Hospital Universitario Gregorio Marañón

C/ Dr Esquerdo nº46 Entrada C/ Maiquez, 7
28007 Madrid
Spain

22

Hospital Universitario Miguel Servet

Paseo de Isabel la Católica 1-3 Edificio Maternidad, planta 8
50009 Zaragoza
Spain

23

Hospital Universitario 12 de Octubre

Avenue Andalucia s/n Edif. Maternidad - Planta 2
28041 Madrid
Spain

24

Hospital Universitari i Politecnic La Fe

Bulevar Sur s/n Oncologia, Planta 7
46026 Valencia
Spain

25

Hospital Universitari Vall d'Hebron

Passeig Vall d'Hebron 119-129 Servicio de Oncologia, Edifici Modul Blau - Planta baixa
08035 Barcelona
Spain

26

Hospital Alvaro Cunqueiro

Estrada Clara Campoamor, 341 Babío - Beade
36312 Vigo pontevedra
Spain

27

Hospital Clinico Universitario de Valencia

Avenida Blasco Ibañez, 17
46010 Valencia
Spain

28

Hospital Clinic de Barcelona

Villarroel 170
08036 Barcelona
Spain

29

Complejo Hospitalario de Toledo

Avenida Barber, 30
45004 Toledo
Spain

30

Complejo Hospitalario de Navarra

c/ Irunlarrea, 3 Oncologia - pabellon C bajo Hospital del día
31008 Pamplona
Spain

31

Centro Integral Oncologico Clara Campal

Oña, 10
28050 Madrid
Spain

32

UMC Utrecht

Heidelberglaan 100 Huispostnummer B05.256
3584 CX Utrecht
Netherlands

33

Tweesteden Ziekenhuis, Tilburg

Dr. Deelenlaan 5
5042 AD Tilburg
Netherlands

34

St. Antonius Ziekenhuis

Koekoekslaan 1 Postbus 2500, 3430 EM
3430 EM Nieuwegein
Netherlands

35

Academisch Medisch Centrum

Meibergdreef 9
1105 AZ Amsterdam
Netherlands

36

Shizuoka Cancer Center

Nagaizumi-cho Shimonagakubo 1007 Shizuoka-Ken
Sunto gun,
411-8777
Japan

37

NHO Osaka National Hospital

Chuo-ku Hoenzaka 2-1-14
Osaka shi,
540-0006
Japan

38

National Cancer Center Hospital East

Kashiwanoha 6-5-1 Chiba-Ken
Kashiwa shi,
277-8577
Japan

39

NHO Kyushu Cancer Center

Minami-ku Notame 3-1-1
Fukuoka shi,
811-1395
Japan

40

Aichi Cancer Center Hospital

Chikusa-ku Kanokoden 1-1
Nagoya shi,
464-8681
Japan

41

Cancer Institute Hospital of JFCR

Ariake 3-8-31 Tokyo-To
Koto ku,
135-8550
Japan

42

Istituto per la Ricerca e la Cura del Cancro

Strada Provinciale 142 Fondazione del Piemonte per l'Oncologia IRCC Candiolo
10060 Candiolo torino
Italy

43

Ist Scientif Romagnolo Per Lo Studio et la Cura dei Tumori

Via P. Maroncelli, 40
47014 Meldola
Italy

44

IRCCS Ospedale Casa Sollievo della Sofferenza

Viale Cappuccini 1 Liver Unit IRCCS San Giovanni Rotondo
71013 San giovanni rotondo
Italy

45

Azienda Ospedaliero Universitaria San Martino

Largo Rosanna Benzi 10
16132 Genova
Italy

46

Azienda Ospedaliera di Perugia Ospedale S. Maria della Miser

Via G. Dottori, 1 Località S. Andrea delle Fratte
06132 Perugia
Italy

47

Universitaetsklinikum Freiburg

Hugstetterstr. 55
79106 Freiburg
Germany

48

Universitaetsklinikum Hamburg-Eppendorf

Martinistrasse 52
20146 Hamburg
Germany

49

Asklepios Klinik Altona

Paul-Ehrlich-Str. 1
22763 Hamburg
Germany

50

Institut Regional du Cancer de Montpellier

Parc Euromedecine 208, rue des Apothicaires
34298 Montpellier
France

51

ICO - Site René Gauducheau

Boulevard Jacques Monod
44805 Saint herblain
France

52

Hôpital de la Timone

264 rue Saint Pierre
13385 Marseille
France

53

Hôpital Saint Antoine

184 Rue du faubourg Saint-Antoine
75571 Paris
France

54

Hôpital Haut-Leveque

Avenue de MAGELLAN – Bât. Magellan 2 – RDC Unité de recherche
33604 Pessac
France

55

Hôpital Européen Georges Pompidou

20, rue Leblanc
75015 Paris
France

56

Hôpital Cochin

CIC Cochin Pasteur CIC 1417 27, rue du Faubourg St Jacques Batiment Lavoisier
75679 Paris
France

57

Clinique Victor Hugo - Centre Jean Bernard

18, rue Victor Hugo
72015 Le mans
France

58

CHU de Toulouse - Hôpital Rangueil

1 Avenue du Pr Jean Pouhlès
31059 Toulouse
France

59

CHU Brest - Hôpital Morvan

5 avenue Foch
29609 Brest
France

60

CHU Besançon - Hôpital Jean Minjoz

3 Boulevard Alexandre Fleming
25030 Besancon
France

61

ZNA Middelheim

Lindendreef 1
2020 Antwerpen
Belgium

62

Universitair Ziekenhuis Gent

De Pintelaan 185 Vijverpark – Entrance, 1ste verdieping
9000 Gent
Belgium

63

AZ Sint-Lucas - Campus Sint-Lucas

Groenebriel 1
9000 Gent
Belgium

64

Cliniques Universitaires Saint-Luc

Avenue Hippocrate 10 Nephrology (Néphrologie) route 418
1200 Bruxelles
Belgium

65

Universitaire Hospital Gasthuisberg

Herestraat 49 UZ Leuven Campus Gasthuisberg
3000 Leuven
Belgium

66

Landesklinikum Wiener Neustadt

Corvinusring 3-5
2700 Wiener neustadt
Austria

67

LKH - Universitätsklinikum der PMU Salzburg

Müllner Hauptstrasse 48 3rd Medical Department with Hematology, Medical Oncology
5020 Salzburg
Austria

68

Krankenhaus der Barmherzigen Brueder Wien

Johannes von Gott Platz 1
1020 Wien
Austria

Last update at : 15 November 2023

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